Diagnostic value of blood thiamine metabolites in Alzheimer’s disease examined by 11C-PiB PET scanning

نویسندگان

  • Zhichun Chen
  • Xiaoli Pan
  • Guoqiang Fei
  • Shumei Pan
  • Weiqi Bao
  • Shuhua Ren
  • Yihui Guan
  • Chunjiu Zhong
چکیده

AIM We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with 11C-Pittsburgh compound B (11C-PiB PET) scanning. METHODS Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received 11C-PiB PET scanning for the measurement of cerebral amyloid deposition. RESULTS Thiamine diphosphate (TDP) had 66.7% sensitivity and 80.0% specificity for AD diagnosis, while the γ-value representing the best combination of thiamine metabolites and age had 24.2% sensitivity and 100.0% specificity according to the cut-off value of our previous study. CONCLUSION Blood TDP but not γ-value exhibited results significant for AD diagnosis.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2017